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      Time-Based Data in Occupational Studies: The Whys, the Hows, and Some Remaining Challenges in Compositional Data Analysis (CoDA)

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          Abstract

          Data on the use of time in different exposures, behaviors, and work tasks are common in occupational research. Such data are most often expressed in hours, minutes, or percentage of work time. Thus, they are constrained or ‘compositional’, in that they add up to a finite sum (e.g. 8 h of work or 100% work time). Due to their properties, compositional data need to be processed and analyzed using specifically adapted methods. Compositional data analysis (CoDA) has become a particularly established framework to handle such data in various scientific fields such as nutritional epidemiology, geology, and chemistry, but has only recently gained attention in public and occupational health sciences. In this paper, we introduce the reader to CoDA by explaining why CoDA should be used when dealing with compositional time-use data, showing how to perform CoDA, including a worked example, and pointing at some remaining challenges in CoDA. The paper concludes by emphasizing that CoDA in occupational research is still in its infancy, and stresses the need for further development and experience in the use of CoDA for time-based occupational exposures. We hope that the paper will encourage researchers to adopt and apply CoDA in studies of work exposures and health.

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          The Statistical Analysis of Compositional Data

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            Combined Effects of Time Spent in Physical Activity, Sedentary Behaviors and Sleep on Obesity and Cardio-Metabolic Health Markers: A Novel Compositional Data Analysis Approach

            The associations between time spent in sleep, sedentary behaviors (SB) and physical activity with health are usually studied without taking into account that time is finite during the day, so time spent in each of these behaviors are codependent. Therefore, little is known about the combined effect of time spent in sleep, SB and physical activity, that together constitute a composite whole, on obesity and cardio-metabolic health markers. Cross-sectional analysis of NHANES 2005–6 cycle on N = 1937 adults, was undertaken using a compositional analysis paradigm, which accounts for this intrinsic codependence. Time spent in SB, light intensity (LIPA) and moderate to vigorous activity (MVPA) was determined from accelerometry and combined with self-reported sleep time to obtain the 24 hour time budget composition. The distribution of time spent in sleep, SB, LIPA and MVPA is significantly associated with BMI, waist circumference, triglycerides, plasma glucose, plasma insulin (all p<0.001), and systolic (p<0.001) and diastolic blood pressure (p<0.003), but not HDL or LDL. Within the composition, the strongest positive effect is found for the proportion of time spent in MVPA. Strikingly, the effects of MVPA replacing another behavior and of MVPA being displaced by another behavior are asymmetric. For example, re-allocating 10 minutes of SB to MVPA was associated with a lower waist circumference by 0.001% but if 10 minutes of MVPA is displaced by SB this was associated with a 0.84% higher waist circumference. The proportion of time spent in LIPA and SB were detrimentally associated with obesity and cardiovascular disease markers, but the association with SB was stronger. For diabetes risk markers, replacing SB with LIPA was associated with more favorable outcomes. Time spent in MVPA is an important target for intervention and preventing transfer of time from LIPA to SB might lessen the negative effects of physical inactivity.
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              Isotemporal substitution paradigm for physical activity epidemiology and weight change.

              For a fixed amount of time engaged in physical activity, activity choice may affect body weight differently depending partly on other activities' displacement. Typical models used to evaluate effects of physical activity on body weight do not directly address these substitutions. An isotemporal substitution paradigm was developed as a new analytic model to study the time-substitution effects of one activity for another. In 1991-1997, the authors longitudinally examined the associations of discretionary physical activities, with varying activity displacements, with 6-year weight loss maintenance among 4,558 healthy, premenopausal US women who had previously lost >5% of their weight. Results of isotemporal substitution models indicated widely heterogeneous relations with each physical activity type (P < 0.001) depending on the displaced activities. Notably, whereas 30 minutes/day of brisk walking substituted for 30 minutes/day of jogging/running was associated with weight increase (1.57 kg, 95% confidence interval: 0.33, 2.82), brisk walking was associated with lower weight when substituted for slow walking (-1.14 kg, 95% confidence interval: -1.75, -0.53) and with even lower weight when substituted for TV watching. Similar heterogeneous relations with weight change were found for each activity type (TV watching, slow walking, brisk walking, jogging/running) when displaced by other activities across these various models. The isotemporal substitution paradigm may offer new insights for future public health recommendations.
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                Author and article information

                Journal
                Ann Work Expo Health
                Ann Work Expo Health
                annhyg
                Annals of Work Exposures and Health
                Oxford University Press (UK )
                2398-7308
                2398-7316
                October 2020
                01 July 2020
                01 July 2020
                : 64
                : 8
                : 778-785
                Affiliations
                [1 ] National Research Centre for the Working Environment, Department of Musculoskeletal Disorders and Physical Work Demands , Copenhagen Ø, Denmark
                [2 ] Section of Social Medicine, Department of Public Health, University of Copenhagen , Copenhagen, Denmark
                [3 ] Department of Sports Science and Clinical Biomechanics, University of Southern Denmark , Odense, Denmark
                [4 ] Centre for Musculoskeletal Research, Department of Occupational Health Sciences and Psychology, University of Gävle , Gävle, Sweden
                Author notes
                Author to whom correspondence should be addressed. Tel: +45-39165309; e-mail: ngu@ 123456nfa.dk
                Article
                wxaa056
                10.1093/annweh/wxaa056
                7544002
                32607544
                4fb037cc-c563-4afa-99c1-561b79fac676
                © The Author(s) 2020. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                : 04 December 2019
                : 04 May 2020
                : 06 May 2020
                : 19 May 2020
                Page count
                Pages: 8
                Funding
                Funded by: Danish Working Environment Research;
                Award ID: 01-2015-09
                Award ID: 01-2015-03
                Funded by: Swedish Research Council for Health;
                Funded by: Working Life and Welfare;
                Award ID: 2009-1761
                Categories
                Commentaries
                AcademicSubjects/MED00640

                constrained data,ergonomics,isometric log-ratio,work environment

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