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      Executable cell biology.

      1 ,
      Nature biotechnology
      Springer Science and Business Media LLC

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          Abstract

          Computational modeling of biological systems is becoming increasingly important in efforts to better understand complex biological behaviors. In this review, we distinguish between two types of biological models--mathematical and computational--which differ in their representations of biological phenomena. We call the approach of constructing computational models of biological systems 'executable biology', as it focuses on the design of executable computer algorithms that mimic biological phenomena. We survey the main modeling efforts in this direction, emphasize the applicability and benefits of executable models in biological research and highlight some of the challenges that executable biology poses for biology and computer science. We claim that for executable biology to reach its full potential as a mainstream biological technique, formal and algorithmic approaches must be integrated into biological research. This will drive biology toward a more precise engineering discipline.

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          Author and article information

          Journal
          Nat Biotechnol
          Nature biotechnology
          Springer Science and Business Media LLC
          1087-0156
          1087-0156
          Nov 2007
          : 25
          : 11
          Affiliations
          [1 ] Microsoft Research, Cambridge CB3 0FB, UK. jasmin.fisher@microsoft.com
          Article
          nbt1356
          10.1038/nbt1356
          17989686
          45a81d95-e043-4073-9271-1adb69e97d39
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