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      Neuropsychological Deficits in Participants at Clinical High-Risk for Psychosis Recruited from the Community: Relationships to Functioning and Clinical Symptoms

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          Abstract

          Background

          The current study examined the pattern of neurocognitive impairments in a community-recruited sample of clinical high-risk (CHR) participants and established relationships with psychosocial functioning.

          Methods

          CHR-participants (n = 108), participants who did not fulfil CHR-criteria (CHR-negatives) (n = 42) as well as a group of healthy controls (HCs) (n = 55) were recruited. CHR-status was assessed using the Comprehensive Assessment of At-Risk Mental State (CAARMS) and the Schizophrenia Proneness Interview, Adult Version (SPI-A). The Brief Assessment of Cognition in Schizophrenia Battery (BACS) as well as tests for emotion recognition, working memory and attention were administered. In addition, role and social functioning as well as premorbid adjustment were assessed.

          Results

          CHR-participants were significantly impaired on the Symbol-Coding and Token-Motor task and showed a reduction in total BACS-scores. Moreover, CHR-participants were characterized by prolonged reactions times (RTs) in emotion recognition as well by reductions in both social and role functioning, GAF and premorbid adjustments compared to HCs. Neurocognitive impairments in emotion recognition accuracy, emotion recognition RT, processing speed and motor speed were associated with several aspects of functioning explaining between 4-12% of the variance.

          Conclusion

          The current data obtained from a community sample of CHR-participants highlight the importance of dysfunctions in motor and processing speed and emotion recognition RT. Moreover, these deficits were found to be related to global, social and role functioning, suggesting that neurocognitive impairments are an important aspect of sub-threshold psychotic experiences and a possible target for therapeutic interventions.

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          Author and article information

          Journal
          1254142
          Psychol Med
          Psychol Med
          Psychological medicine
          0033-2917
          1469-8978
          18 January 2019
          13 March 2019
          January 2020
          08 January 2020
          : 50
          : 1
          : 77-85
          Affiliations
          [1 ]Institute for Neuroscience and Psychology, Univ. of Glasgow, U.K.
          [2 ]Institute of Biomagnetism and Biosignalanalysis, Westphalian Wilhelms University Muenster, Germany
          [3 ]Institute of Health and Wellbeing, Univ. of Glasgow, U.K.
          [4 ]Department of Psychiatry, Univ. of Edinburgh, U.K.
          [5 ]Department of Clinical Psychology, Univ. Edinburgh, U.K.
          [6 ]University Hospital of Child and Adolescent Psychiatry and Psychotherapy, Univ. of Bern, Bern, Switzerland
          [7 ]Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University Düsseldorf, Germany
          Author notes
          Corresponding Author: Dr. Peter J. Uhlhaas, Institute of Neuroscience and Psychology, 58 Hillhead Street, University of Glasgow, G12 8QB, Scotland, peter.uhlhaas@ 123456glasgow.ac.uk , Tel: 0044/ 141 330 8730
          [*]

          Joint First Authors

          Article
          PMC6949121 PMC6949121 6949121 ems81193
          10.1017/S0033291718003975
          6949121
          30862319
          3afe2a96-ce0a-4cdf-80cf-7eaffdf9e177
          History
          Categories
          Article

          Prevention,Functioning,Neurocognition,Psychosis,Clinical High-Risk

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