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      Prevalencia de marcadores de infecciones transmisibles y su relación con variables demográficas en un banco de sangre de Antioquia-Colombia, 2010-2013 Translated title: Prevalence of markers of transmissible infections in a blood bank of Antioquia, Colombia, 2010-2013

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          Abstract

          Introducción: las infecciones transmisibles por vía transfusional presentan divergencias en su magnitud y factores asociados, en correspondencia con el perfil epidemiológico de la población de referencia de cada banco de sangre. Objetivo: establecer la prevalencia de marcadores de infecciones transmisibles por vía transfusional y sus factores demográficos relacionados en un banco de sangre de Antioquia, en el periodo 2010-2013. Métodos: estudio transversal en donantes de un banco de sangre de Antioquia en quienes se aplicaron los criterios de inclusión de la resolución 901 de 1996. La fuente de información fue secundaria y los análisis de los marcadores de infecciones y sus factores relacionados se basaron en el cálculo de medidas de resumen, prueba chi cuadrado, razones de prevalencia y evaluación de la confusión por regresión logística binaria. Resultados: se incluyeron 15 461 donantes con edad promedio de 36 años.La prevalencia de positividad para cualquier marcador fue 1,18 %, de infecciones virales 0,15 %, de Treponema pallidum 1,00 % y de T. cruzi del 0,02 %. La prevalencia global de infecciones y de T. pallidum fue estadísticamente mayor en hombres, personas de mayor edad, donantes de reposición y ocupación de "servicios, deportes y recreación" y amas de casa; en el análisis multivariado se demostró que estas asociaciones no presentaron confusión. Conclusión: la prevalencia de infecciones fue muy baja y menor en comparación con investigaciones previas, los subgrupos con una prevalencia estadísticamente mayor fueron los hombres, donantes de reposición y personas de mayor edad; esto permite la orientación de investigaciones y acciones sanitarias posteriores.

          Translated abstract

          Introduction: Transfusion transmissible infections present differences in magnitude and associated factors according to the epidemiological profile of the reference population of each blood bank. Objective: To determine the prevalence of markers of transfusion transmissible infections and associated factors in a Blood Bank Antioquia, 2010-2013. Methods: Cross-Sectional study of prevalence in donors from a blood bank Antioquia in whom inclusion criteria of resolution 901 of 1996 were applied. The source information was secondary and the analyzes were based on the calculation of summary measures, proportions, chi square test, prevalence ratios and evaluation of confusing by binary logistic regression. Results: We included 15 461 donors with a mean age of 36 years. The prevalence of positivity for any marker was 1.18 %, viral infections 0.15 %, Treponema pallidum 1.00 % and T. cruzi 0.02 %. The overall prevalence and of T. pallidum infection was statistically higher in men, elderly, replacement donors and persons with occupation of "services, sports and recreation" and housewives, in the multivariate analysis it showed that these associations did not present confusion. Conclusion: The prevalence of infection was lower compared to previous researches; the subgroups with statistically higher prevalence were men, replacement donors and elderly, this constitute a finding of interest for targeting investigations and health actions.

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            Sero-epidemiology of transfusion-transmissible infectious diseases among blood donors in Osogbo, south-west Nigeria.

            Transfusion-transmissible infectious agents such as hepatitis B virus (HBV), human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem. This cross-sectional study was undertaken with the aim of determining the seroprevalence of HIV, HCV, hepatitis B surface antigen (HBsAg) and syphilis and correlates the findings with sex and age to ascertain the associations, if any, in the occurrence of the pathogens. HBsAg, antibodies to Treponema pallidum and HCV were determined using Clinotech test strips. Antibodies to HIV types 1 and 2 were screened with Determine and Immunocomb. All the reactive samples were confirmed using enzyme-linked immunosorbent assays. Antibodies to Treponema pallidum were confirmed with a Treponema pallidum haemagglutination test. A total of 1,410 apparently healthy prospective blood donors aged between 18 and 64 years (mean+/-SD, 32.58 +/- 10.24 years) who presented for blood donation at the Ladoke Akintola University of Technology Teaching Hospital Blood Bank, Osogbo were studied. The male:female ratio was 6:1. Of the prospective blood donors, 406 (28.8%) had serological evidence of infection with at least one infectious marker and 36 (2.6%) had dual infections. The overall seroprevalence of HBsAg, HIV, HCV and syphilis was found to be 18.6%, 3.1%, 6.0% and 1.1%, respectively. The highest prevalences of HBsAg, HIV, HCV and syphilis infections occurred among commercial blood donors and those aged 18 to 47 years old, the most sexually active age group. There were no significant associations between pathogens except for syphilis and HIV (p > 0.001). The high seroprevalence of blood-borne pathogens among prospective blood donors in Osogbo, Nigeria calls for mandatory routine screening of blood donors for HBV, HIV, HCV and syphilis.
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              Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis among blood donors in Koudougou (Burkina Faso) in 2009.

              The high prevalence of numerous transfusion-transmitted infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis in sub-Saharan Africa affects the safety of blood for recipients. This study was undertaken with the aim of determining the seroprevalence of HIV, HCV, HBV, syphilis and socio-demographic risk factors associated with blood donation in a new regional blood transfusion centre in Burkina Faso. Sera samples were screened for hepatitis B surface antigen (HBsAg), antibodies to HCV, HIV types 1 and 2 and to Treponema pallidum using enzyme-linked immunosorbent assays and Rapid Plasma Reagin test (RPR) respectively. All the reactive samples for HIV, HBsAg, and HCV were confirmed using a second enzyme-linked immunosorbent assays. Antibodies to Treponema pallidum were confirmed with a Treponema pallidum haemagglutination test (TPHA). From the total of 4,520 blood donors in 2009, 1,348 (29.82%) were infected with at least one pathogen and 149 (3.30%) had serological evidence of multiple infections. The overall seroprevalence rate of HIV, HBV, HCV and syphilis was 2.21%, 14.96%, 8.69% and 3.96%, respectively. Among blood donors with multiples infections, the most common dual or triple combinations were HBsAg-HCV (1.39%), HBsAg-syphilis (0.66%) and HBsAg-HCV-syphilis (0.11%). The highest prevalences of HBsAg and HIV were found among blood donors from rural areas and in the age groups of 20-29 years and >40 years old, respectively. HBV and HCV remain the greatest threats to blood safety in Burkina Faso. Strict selection and retention of voluntary, non-remunerated low-risk blood donors are recommended to improve blood safety in the regional blood transfusion centre of Koudougou.
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                Author and article information

                Journal
                cesm
                CES Medicina
                CES Med.
                Universidad CES (Medellín, Antioquia, Colombia )
                0120-8705
                June 2015
                : 29
                : 1
                : 59-73
                Affiliations
                [02] orgnameBanco de Sangre de Rionegro
                [03] Medellín orgnameUniversidad de Antioquia orgdiv1Universidad Cooperativa Colombia
                [01] Medellín orgnameUniversidad CES Colombia
                Article
                S0120-87052015000100006 S0120-8705(15)02900106
                39064793-e515-40cb-ac00-2004c98e6e8d

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 11 March 2015
                : 18 June 2015
                : 06 July 2015
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 32, Pages: 15
                Product

                SciELO Colombia

                Categories
                Artículo de investigación científica o tecnológica

                Trypanosoma cruzi,HIV Infections,Syphilis,Hepatitis viruses,Prevalence,Blood banks,Virus de la hepatitis,Sífilis,Prevalencia Infecciones por VIH,Bancos de sangre

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