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      Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine

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      1 , 2 , 1 , 2 , *
      Cell

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          Abstract

          Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.

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          Author and article information

          Journal
          0413066
          2830
          Cell
          Cell
          Cell
          0092-8674
          1097-4172
          7 June 2016
          2 June 2016
          02 June 2017
          : 165
          : 6
          : 1319-1322
          Affiliations
          [1 ]Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
          [2 ]Center for RNA Biology, University of Rochester, Rochester, NY 14642, USA
          Author notes
          Article
          PMC4924582 PMC4924582 4924582 nihpa788559
          10.1016/j.cell.2016.05.053
          4924582
          27259145
          2d5b5db1-5104-41f3-adf6-a00f33b984c6
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