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      Antifibrotic activity of conjugates based on amphiphilic pluronic F68 and hydrophobic pluronic L31 with hyaluronate-endo-β-N-acetylhexosaminidase in pulmonary fibrosis.

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          Abstract

          Antifibrotic activity of intranasally administered conjugates of pluronics L31 and F68 with hyaluronate-endo-β-N-acetylhexosaminidase was studied in C57Bl/6 mice under conditions of single and repeated bleomycin-induced injury to the alveolar epithelium. Conjugates were prepared using the technique of protein immobilization with ionizing radiation. We demonstrate that in cases of single and repeated injuries to the alveolar epithelium, the conjugates administered during phases of inflammation or deposition of fibrotic masses prevent the development of pulmonary fibrosis. The conjugates demonstrated more pronounced antifibrotic activity than hyaluronate-endo-β-N-acetylhexosaminidase. The conjugate based on hydrophobic pluronic L31 showed higher effectiveness in comparison with the conjugate based on amphiphilic pluronic F68.

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          Author and article information

          Journal
          Bull Exp Biol Med
          Bulletin of experimental biology and medicine
          Springer Science and Business Media LLC
          1573-8221
          0007-4888
          May 2014
          : 157
          : 1
          Affiliations
          [1 ] Department of Pathophysiology and Regenerative Medicine Research Institute of Pharmacology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia.
          Article
          10.1007/s10517-014-2478-0
          24906958
          2aa93e62-3a7e-4057-ab25-e0f2d415a7b3
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