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      Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles.

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          Abstract

          The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer that protects its content, PDNPs are a viable model for the design of innovative delivery systems. In this review, a summary of the prerequisites for mammalian extracellular vesicles to serve as delivery vehicles will be given. After that, we will concentrate on providing a thorough overview of the studies investigating the interactions of plant-derived nanoparticles with mammalian systems as well as the loading strategies for encapsulating therapeutic molecules. Finally, the existing challenges in establishing PDNPs as reliable biological delivery systems will be emphasized.

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          Author and article information

          Journal
          Plants (Basel)
          Plants (Basel, Switzerland)
          MDPI AG
          2223-7747
          2223-7747
          Mar 07 2023
          : 12
          : 6
          Affiliations
          [1 ] Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
          [2 ] Biomedical Sciences, School of Health, Leeds Beckett University, Leeds LS1 3HE, UK.
          [3 ] Centre for Plant Sciences, University of Leeds, Leeds LS1 3HE, UK.
          Article
          plants12061207
          10.3390/plants12061207
          10053153
          36986896
          2a9c0a53-1cad-41cd-84de-6d0a91a416cb
          History

          sonication,co-incubation,drug delivery,microRNA,plant-derived nanoparticles (PDNPs)

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