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      Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

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          Abstract

          Osteosarcoma is the most prevalent bone malignant tumor in children and teenagers. The bone defect, recurrence, and metastasis after surgery severely affect the life quality of patients. Clinically, bone grafts are implanted. Primary bioceramic scaffolds show a monomodal osteogenesis function. With the advances in three-dimensional printing technology and materials science, while maintaining the osteogenesis ability, scaffolds become more patient-specific and obtain additional anti-tumor ability with functional agents being loaded. Anti-tumor therapies include photothermal, magnetothermal, old and novel chemo-, gas, and photodynamic therapy. These strategies kill tumors through novel mechanisms to treat refractory osteosarcoma due to drug resistance, and some have shown the potential to reverse drug resistance and inhibit metastasis. Therefore, multifunctional three-dimensional printed bioceramic scaffolds hold excellent promise for osteosarcoma treatments. To better understand, we review the background of osteosarcoma, primary 3D-printed bioceramic scaffolds, and different therapies and have a prospect for the future.

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              Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

              The development, perspectives, and challenges of photothermal therapy (PTT) and photoacoustic imaging (PAI) via nanotheranostics for combating cancer. The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis of cancer, respectively. By taking advantage of nanocarriers, both imaging and therapeutic functions together with enhanced tumour accumulation have been thoroughly studied to improve the pre-clinical efficiency of PAI and PTT. In this review, we first summarize the development of inorganic and organic nano photothermal transduction agents (PTAs) and strategies for improving the PTT outcomes, including applying appropriate laser dosage, guiding the treatment via imaging techniques, developing PTAs with absorption in the second NIR window, increasing photothermal conversion efficiency (PCE), and also increasing the accumulation of PTAs in tumours. Second, we introduce the advantages of combining PTT with other therapies in cancer treatment. Third, the emerging applications of PAI in cancer-related research are exemplified. Finally, the perspectives and challenges of PTT and PAI for combating cancer, especially regarding their clinical translation, are discussed. We believe that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve our ability to combat cancers.
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                Author and article information

                Journal
                J Tissue Eng
                J Tissue Eng
                TEJ
                sptej
                Journal of Tissue Engineering
                SAGE Publications (Sage UK: London, England )
                2041-7314
                15 May 2023
                Jan-Dec 2023
                : 14
                : 20417314231170371
                Affiliations
                [1 ]Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
                [2 ]Shanghai Jiao Tong University School of Medicine, Shanghai, China
                [3 ]Southwest Jiaotong University, Chengdu, China
                [4 ]Department of Orthopaedic Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, China
                [5 ]Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
                [6 ]Shanghai Jiao Tong University, Shanghai, China
                [7 ]Weifang Medical University School of Rehabilitation Medicine, Weifang, Shandong Province, China
                Author notes
                [*]Jinwu Wang, Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, China. Email: wangjw-team@ 123456shsmu.edu.cn
                [*]Shuai Li, Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang 310003, China. Email: allenle1991@ 123456sina.com
                [*]Pengfei Zheng, Department of Orthopaedic Surgery, Children’s Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing, Jiangsu 210008, China. Email: zhengpengfei@ 123456njmu.edu.cn
                [*]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-2883-7836
                https://orcid.org/0000-0002-8647-4818
                https://orcid.org/0000-0003-1411-057X
                Article
                10.1177_20417314231170371
                10.1177/20417314231170371
                10186582
                37205149
                29013047-da65-4c05-b49d-f8a63b54a9e7
                © The Author(s) 2023

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                : 11 January 2023
                : 31 March 2023
                Funding
                Funded by: jiangsu provincial key research and development program, FundRef https://doi.org/10.13039/501100013058;
                Award ID: BE2019608
                Funded by: china postdoctoral science foundation, FundRef https://doi.org/10.13039/501100002858;
                Award ID: 2020TQ0195
                Funded by: china postdoctoral science foundation, FundRef https://doi.org/10.13039/501100002858;
                Award ID: 2021M702165
                Funded by: Translation Medicine National Key Science and Technology Infrastructure (Shanghai) Open Project, ;
                Award ID: TMSK-2020-118
                Funded by: school of medicine, shanghai jiao tong university, FundRef https://doi.org/10.13039/501100008233;
                Award ID: 1521Y037
                Funded by: iangsu Health Commission Medical Research Program, ;
                Award ID: 2020158
                Funded by: 2022 Lingang laboratory “Seeking Outstanding Youth Program” open project, ;
                Award ID: LG-QS-202206-04
                Funded by: National Key Research and Development Program of China, FundRef https://doi.org/10.13039/501100012166;
                Award ID: 2018YFA0703000
                Categories
                Review Article
                Custom metadata
                January-December 2023
                ts1

                Biomedical engineering
                osteosarcoma treatment,anti-tumor,osteogenesis,functional agents,multifunctional 3d-printed bioceramic scaffolds

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