21
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Bacillus subtilis extracytoplasmic function (ECF) sigma factors and defense of the cell envelope

      research-article
      Current opinion in microbiology

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Summary

          Bacillus subtilis provides a model for investigation of the bacterial cell envelope, the first line of defense against environmental threats. Extracytoplasmic function (ECF) sigma factors activate genes that confer resistance to agents that threaten the integrity of the envelope. Although their individual regulons overlap, σ W is most closely associated with membrane-active agents, σ X with cationic antimicrobial peptide resistance, and σ V with resistance to lysozyme. Here, I highlight the role of the σ M regulon, which is strongly induced by conditions that impair peptidoglycan synthesis and includes the core pathways of envelope synthesis and cell division, as well as stress-inducible alternative enzymes. Studies of these cell envelope stress responses provide insights into how bacteria acclimate to the presence of antibiotics.

          Related collections

          Author and article information

          Contributors
          Journal
          9815056
          21196
          Curr Opin Microbiol
          Curr. Opin. Microbiol.
          Current opinion in microbiology
          1369-5274
          1879-0364
          24 February 2016
          20 February 2016
          April 2016
          01 April 2017
          : 30
          : 122-132
          Affiliations
          Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
          Author notes
          For correspondence: jdh9@ 123456cornell.edu , Phone: 607-255-6570
          Article
          PMC4821709 PMC4821709 4821709 nihpa762073
          10.1016/j.mib.2016.02.002
          4821709
          26901131
          27c98ebb-f957-4373-a9bc-e4020c36379f
          History
          Categories
          Article

          Comments

          Comment on this article