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      Unsung Renal Receptors: Orphan G-protein coupled receptors play essential roles in renal development and homeostasis

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      Acta physiologica (Oxford, England)
      Orphan GPCRs, Ligands, Function, Kidney

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          Abstract

          Recent studies have shown that orphan GPCRs of the GPR family are utilized as specialized chemosensors in various tissues to detect metabolites, and in turn to activate downstream pathways which regulate systemic homeostasis. These studies often find that such metabolites are generated by well-known metabolic pathways, implying that known metabolites and chemicals may perform novel functions. In this review, we summarize recent findings highlighting the role of deorphanized GPRs in renal development and function. Understanding the role of these receptors is critical in gaining insights into mechanisms that regulate renal function both in health and in disease.

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          Author and article information

          Journal
          101262545
          32806
          Acta Physiol (Oxf)
          Acta Physiol (Oxf)
          Acta physiologica (Oxford, England)
          1748-1708
          1748-1716
          6 October 2016
          23 October 2016
          June 2017
          01 June 2018
          : 220
          : 2
          : 189-200
          Affiliations
          Department of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
          Author notes
          [* ]Corresponding Author: 725 N Wolfe Street, 205 WBSB, Johns Hopkins School of Medicine, Baltimore, MD 21205. jpluznick@ 123456jhmi.edu
          Article
          PMC5378694 PMC5378694 5378694 nihpa821145
          10.1111/apha.12813
          5378694
          27699982
          257b00d6-12dc-4dc1-b570-cd5283361af0
          History
          Categories
          Article

          Orphan GPCRs,Kidney,Function,Ligands
          Orphan GPCRs, Kidney, Function, Ligands

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