Pretreatment Reward Sensitivity and Frontostriatal Resting-State Functional Connectivity Are Associated With Response to Bupropion After Sertraline Nonresponse.

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Abstract

Standard guidelines recommend selective serotonin reuptake inhibitors as first-line antidepressants for adults with major depressive disorder, but success is limited and patients who fail to benefit are often switched to non-selective serotonin reuptake inhibitor agents. This study investigated whether brain- and behavior-based markers of reward processing might be associated with response to bupropion after sertraline nonresponse.

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Author and article information

Journal

Journal ID (iso-abbrev): Biol Psychiatry

Title: Biological psychiatry

Publisher: Elsevier BV

ISSN (Electronic): 1873-2402

ISSN (Print): 0006-3223

Publication date (Electronic): October 15 2020

Volume: 88

Issue: 8

Affiliations

[1 ] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts.

[2 ] Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado.

[3 ] Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.

[4 ] Department of Psychiatry, University of Texas at Austin, Dell Medical School, Austin, Texas.

[5 ] Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.

[6 ] Department of Psychiatry, Stony Brook University, Stony Brook, New York.

[7 ] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.

[8 ] New York State Psychiatric Institute and Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.

[9 ] Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.

[10 ] Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.

[11 ] Department of Psychiatry, University of Texas, Southwestern Medical Center, Dallas, Texas.

[12 ] Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts. Electronic address: dap@mclean.harvard.edu.

Article

Publisher Item ID: S0006-3223(20)31516-X Mid ID: NIHMS1587125

DOI: 10.1016/j.biopsych.2020.04.009

PMC ID: 7529779

PubMed ID: 32507389

SO-VID: 1db491c0-386e-4a91-866c-7fad5817f94d

History

Keywords: Biomarkers,Frontostriatal connectivity,Bupropion,Antidepressant response,Sertraline,Reward sensitivity

Data availability:

Keywords: Biomarkers, Frontostriatal connectivity, Bupropion, Antidepressant response, Sertraline, Reward sensitivity

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