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      Simultaneous determinations of paeonol and palmatine hydrochloride in Shangshi Aerosols by HPLC method.

      1 ,
      Journal of pharmaceutical and biomedical analysis
      Elsevier BV

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          Abstract

          A simple and rapid HPLC method was described for the simultaneous determination of paeonol and palmatine hydrochloride in Shangshi Aerosols. The optimum separation for these analytes was achieved using the mixture of 0.025 M sodium dihydrogen phosphate-acetonitrile-diethylamine (64:35:1, v/v/v) as the mobile phase and a Nova-Pak((R)) C8 column. The linear ranges of paeonol and palmatine hydrochloride were 0.2-80 and 0.06-60 microg/ml with the regression equations being Y=11716.4+2.96 x 10(6)X (R=0.99969), Y=-6388.8+1.89 x 10(5)X (R=0.99976), and limit of quantifications (LOQ) for paeonol and palmatine hydrochloride were 0.2 and 0.06 microg/ml, respectively (n=6). Other validation parameters: intra-day precision (R.S.D.: 0.71-1.65%) and inter-day precision (R.S.D.: 0.89-2.11%), and reproducibility (recoveries values: 94.6-98.2% for paeonol, 94.85-97.58% for palmatine hydrochloride) were found to be satisfactory. The proposed HPLC method had been applied for the determination of paeonol and palmatine hydrochloride in Shangshi Aerosols; R.S.D. values were 1.45 and 1.13%, respectively. In short, this method was rapid and convenient, which could be used for the routine control of paeonol and palmatine hydrochloride in Shangshi Aerosols.

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          Author and article information

          Journal
          J Pharm Biomed Anal
          Journal of pharmaceutical and biomedical analysis
          Elsevier BV
          0731-7085
          0731-7085
          Jul 01 2005
          : 38
          : 3
          Affiliations
          [1 ] College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China. zhjw76@hotmail.com
          Article
          S0731-7085(05)00080-4
          10.1016/j.jpba.2005.02.001
          15925262
          198b7ca7-1ef1-4962-bb59-365a4c701f66
          History

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