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      Hydrogen peroxide production and free radical-mediated cell stress in Mycoplasma bovis pneumonia.

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          Abstract

          Mycoplasma bovis causes chronic pneumonia and polyarthritis in feedlot cattle. M. bovis infects the lungs of most feedlot cattle, but the majority of calves never develop disease. Competing explanations are that some strains of M. bovis are more virulent than others or, alternatively, that calves require some other abnormality to be present in order for M. bovis to cause disease. We hypothesize that H2O2 production is an important virulence factor of M. bovis, causing oxidative injury to lung tissue. A second hypothesis is that isolates associated with caseonecrotic bronchopneumonia have an increased capacity for H2O2 production. Immunohistochemical markers of oxidative stress (4-hydroxynonenal, HN) and nitrative stress (3-nitrotyrosine, NT) were compared in lungs of calves with caseonecrotic bronchopneumonia characteristic of M. bovis infection, with other forms of bronchopneumonia or with non-inflamed lungs. HN and NT were identified in M. bovis pneumonia, mainly in foci of caseous necrosis. HN was not observed in inflamed non-necrotic tissue in lesions typical of pneumonic pasteurellosis. H2O2 production by M. bovis was identified, but the levels did not differ in isolates from calves with caseonecrotic bronchopneumonia compared with those with non-inflamed lungs or other forms of pneumonia. These findings provide evidence that oxidative and nitrative injury contribute to the formation of the caseonecrotic lesions that are characteristic of M. bovis pneumonia and that production of H2O2 by M. bovis may contribute to this oxidative injury.

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          Author and article information

          Journal
          J. Comp. Pathol.
          Journal of comparative pathology
          Elsevier BV
          1532-3129
          0021-9975
          September 26 2013
          : 150
          : 2-3
          Affiliations
          [1 ] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
          [2 ] Animal Health Laboratory, Laboratory Services Division, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
          [3 ] Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
          [4 ] Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Electronic address: jcaswell@uoguelph.ca.
          Article
          S0021-9975(13)00129-1
          10.1016/j.jcpa.2013.07.008
          24064048
          1658df73-c508-4802-8dd4-06eec4677752
          History

          pneumonia,oxidative stress,nitric oxide,Mycoplasma bovis

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