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      Prevalence of adverse childhood experiences among individuals in treatment for substance use disorder: are ACE associated differently across type of abuse and quantity of consumption?

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          ABSTRACT

          This study aimed to 1) describe the prevalence of Adverse Childhood Experiences (ACE) in relation to the type of substance used (alcohol or cannabis) among adults seeking treatment for Substance Use Disorder (SUD) in Greenland, and 2) examine whether an association exists between ACE and the type of substance used (alcohol and/or cannabis). The analysis was conducted using register data from individuals receiving SUD treatment in Greenland between 1 June 2020 to 31 December 2022 ( N = 1037). The results showed a higher prevalence and a greater variety of ACE among women compared to men. Among men, no significant associations were found between ACE and the substance categories. However, among women, unstable conditions in the childhood home were associated with high use of either alcohol or cannabis. Additionally, high cannabis use was significantly associated with parent(s) with cannabis abuse and physical abuse for women. No cumulative effect of the number of ACE, and any type of substance abuse was found. Growing up with parents with alcohol problems emerged as the most frequently reported ACE for both sexes (reported by 74.6% of women and 62.7% of men).

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          Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults

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            The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis

            A growing body of research identifies the harmful effects that adverse childhood experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or exposure to domestic violence) have on health throughout life. Studies have quantified such effects for individual ACEs. However, ACEs frequently co-occur and no synthesis of findings from studies measuring the effect of multiple ACE types has been done.
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              The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology.

              Childhood maltreatment has been linked to a variety of changes in brain structure and function and stress-responsive neurobiological systems. Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well-being. After a brief review of the neurobiology of childhood trauma, we use the Adverse Childhood Experiences (ACE) Study as an epidemiological "case example" of the convergence between epidemiologic and neurobiological evidence of the effects of childhood trauma. The ACE Study included 17,337 adult HMO members and assessed 8 adverse childhood experiences (ACEs) including abuse, witnessing domestic violence, and serious household dysfunction. We used the number of ACEs (ACE score) as a measure of cumulative childhood stress and hypothesized a "dose-response" relationship of the ACE score to 18 selected outcomes and to the total number of these outcomes (comorbidity). Based upon logistic regression analysis, the risk of every outcome in the affective, somatic, substance abuse, memory, sexual,and aggression-related domains increased in a graded fashion as the ACE score increased (P <0.001). The mean number of comorbid outcomes tripled across the range of the ACE score. The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions.
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                Author and article information

                Journal
                Int J Circumpolar Health
                Int J Circumpolar Health
                International Journal of Circumpolar Health
                Taylor & Francis
                1239-9736
                2242-3982
                2 January 2025
                2025
                2 January 2025
                : 84
                : 1
                : 2439122
                Affiliations
                [a ]Master of Public Health Student, Aarhus University; , Aarhus, Denmark
                [b ]Allorfik and Center for Health Research in Greenland, University of Greenland; , Nuuk, Greenland
                Author notes
                CONTACT Helena Sandgård Poulsen helena@ 123456vi-fem.dk Master of Public Health Student, Aarhus University, Aarhus, Denmark
                [*]

                These two authors contributed equally to this work.

                Author information
                https://orcid.org/0009-0001-1941-6992
                Article
                2439122
                10.1080/22423982.2024.2439122
                11703386
                39746114
                11064c65-a692-47ad-9716-5dff6653254a
                © 2024 Birgit V. Niclasen. Published by Informa UK Limited, trading as Taylor & Francis Group.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

                History
                Page count
                Figures: 1, Tables: 4, References: 33, Pages: 1, Words: 5114
                Categories
                Research Article
                Original Research Article

                Medicine
                greenland,adverse childhood experiences (ace),arctic,alcohol use,cannabis use,substance abuse treatment,substance use disorder

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