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      Neural Correlates of Autobiographical Problem-Solving Deficits Associated with Rumination in Depression

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          Abstract

          Background

          Analytical rumination can be characterized as negative thoughts focused on searching for answers to personal problems. Failure to think concretely during autobiographical problem-solving (APS) is hypothesized to drive the inability of ruminators to generate effective solutions. Clarifying the brain correlates underlying APS deficits in depressed ruminators may identify novel biological targets for treatment.

          Method

          Forty participants (22 unmedicated depressed and 18 never-depressed adults) ranging in rumination engaged in APS and negative self-referential processing (NSP) of negative trait adjectives during fMRI. We contrasted activation during APS with activation during NSP to isolate regions contributing to APS.

          Results

          Rumination was associated with having generated fewer solutions during APS and with a failure to recruit the angular gyrus (AG) and the medial frontal gyrus (MFG) during APS. Rumination was associated with greater MFG activation during NSP and stronger connectivity between the AG and the rostrolateral prefrontal cortex (RLPFC) during APS relative to NSP. Findings were not driven by clinical status.

          Limitations

          The use of an extreme groups approach can result in overestimation of effects sizes.

          Conclusions

          Ruminators fail to recruit regions with the default network (DN) that support APS. In particular, a failure to recruit the AG during APS may drive the abstract thinking style previously shown to explain depressed ruminator’s difficulty generating concrete solutions. Targeting this mechanism directly may reduce rumination.

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          Author and article information

          Journal
          7906073
          4424
          J Affect Disord
          J Affect Disord
          Journal of affective disorders
          0165-0327
          1573-2517
          4 May 2017
          29 April 2017
          15 August 2017
          15 August 2018
          : 218
          : 210-216
          Affiliations
          Department of Psychiatry, University of Pittsburgh School of Medicine
          Author notes
          [* ]Corresponding Author: Neil P. Jones, Address: Western Psychiatric Institute and Clinic; 3811 O’Hara St.; Pittsburgh PA 15216, USA, Phone: 412.383.5431, Fax: 412.383.5426, jonesnp@ 123456upmc.edu
          Article
          PMC5505343 PMC5505343 5505343 nihpa873535
          10.1016/j.jad.2017.04.069
          5505343
          28477499
          08e84b7b-8fb5-4df8-b82f-23ca15d057b1
          History
          Categories
          Article

          Autobiographical Memory,Problem-Solving,Mental Simulation,fMRI,Rumination,Depression

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